Skin erythrodiapedesis during chronic venous disorders

Background: Extravasation of erythrocytes (erythrodiapedesis [ED]) is currently included among causes of skin damage in legs with chronic venous disorders (CVD) and ascribed to venular hypertension. ED is followed by erythrocyte disruption, degradation of hemoglobin, and storing of ferric iron into hemosiderin. The aim of this study was to evaluate the occurrence of ED in the skin of legs with different clinical stages of CVD. Methods: One hundred eighteen skin biopsies from legs with CVD underwent histologic evaluation for ED and hemosiderin deposition (HD). Results: ED was found in only 21/118 specimens. In particular, it was found in ulcer samples, in tissues surrounding varicophlebitis and, finally, in acute eczematous skin. ED was found in only 15/30 samples showing HD. Conclusion: Our findings confirm the occurrence of ED during CVD. However, it was found only in concomitance of severe dermal inflammation. Hemosiderin deposition in the absence of actual ED could be explained with previous healed episodes of skin inflammation. However, ED is not likely the only cause of skin iron overload, which could also occur by a molecular mechanism. Further studies are needed to define the mechanism of iron deposition in the skin of legs afflicted with CVD. (J Vase Surg 2011;53:1649-53.

Beyond-Luttinger-liquid thermodynamics of a one-dimensional Bose gas with repulsive contact interactions

We present a thorough study of the thermodynamics of a one-dimensional repulsive Bose gas, focusing in particular on corrections beyond the Luttinger-liquid description. We compute the chemical potential, pressure, and contact as a function of temperature and gas parameter with an exact thermal Bethe ansatz. In addition, we provide interpretations of the main features in the analytically tractable regimes, based on a variety of approaches (Bogoliubov, hard core, Sommerfeld, and virial). The beyond-Luttinger-liquid thermodynamic effects are found to be nonmonotonic as a function of gas parameter. Such behavior is explained in terms of nonlinear dispersion and “negative excluded volume” effects, for weak and strong repulsion, respectively, responsible for the opposite sign corrections in the thermal next-to-leading term of the thermodynamic quantities at low temperatures. Our predictions can be applied to other systems including super Tonks-Girardeau gases, dipolar and Rydberg atoms, helium, quantum liquid droplets in bosonic mixtures, and impurities in a quantum bath.Peer ReviewedPostprint (published version

Age-related variations of varicose veins anatomy

Background: Primary varicose veins are commonly considered a progressive disease starting from the saphenous junctions and extending to tributaries in a retrograde fashion along the saphenous trunks. This theory has been criticized by studies indicating different patterns of development and progression of varicose veins. To contribute to the understanding of the pathogenesis of the disease, the anatomy of the venous bed was comparatively evaluated by duplex sonography in patients with varicose veins with a marked difference in age. Methods. The study included 100 varicose limbs in 82 patients aged < 30 years and 238 limbs in 183 patients aged > 60 years. Veins were designated as saphenous veins (SVs), tributaries of the SVs (STVs), and veins not connected with the SVs (NSVs). Four main anatomic patterns were comparatively evaluated: (1) varicose changes only along SVs, (2) varicose changes along SVs and STVs, (3) varicose changes only in STVs, and (4) varicose changes only in NSVs. Results. SVs were normal in 44% of varicose limbs. In most limbs from young subjects, varicose changes afflicted only SVTs (25%) and NSVs (36%). Varicose SVs were more frequent in the older group (62%) than in younger one (39%) owing to a higher prevalence of limbs with combined SV and STV varicosities (respectively, 59% and 37%). In the older group, varicosities in the STVs were more frequently observed in association with incompetence of the SV trunks. Conclusion: The frequent occurrence of normal SVs in varicose limbs of all patients does not support the crucial role commonly credited to SVs in the pathogenesis of primary varicosities. Moreover, the SV trunks were normal in most varicose limbs from young patients. These findings suggest that varicose disease may progressively extend in an antegrade fashion, spreading from the STVs to the SVs. This hypothesis suggests that the saphenous trunks could be spared in the treatment of a relevant number of varicose legs. Prospective longitudinal studies with serial duplex evaluations of large series of extremities are necessary to confirm this hypothesis

Engineering Pervasive Service Ecosystems: The SAPERE approach

Emerging pervasive computing services will typically involve a large number of devices and service components cooperating together in an open and dynamic environment. This calls for suitable models and infrastructures promoting spontaneous, situated, and self-adaptive interactions between components. SAPERE (Self-Aware Pervasive Service Ecosystems) is a general coordination framework aimed at facilitating the decentralized and situated execution of self-organizing and self-adaptive pervasive computing services. SAPERE adopts a nature-inspired approach, in which pervasive services are modeled and deployed as autonomous individuals in an ecosystem of other services and devices, all of which interact in accord to a limited set of coordination laws, or eco-laws. In this article, we present the overall rationale underlying SAPERE and its reference architecture. We introduce the eco-laws--based coordination model and show how it can be used to express and easily enforce general-purpose self-organizing coordination patterns. The middleware infrastructure supporting the SAPERE model is presented and evaluated, and the overall advantages of SAPERE are discussed in the context of exemplary use cases

Lidar And Hyperspectral Data Integration For Landslide Monitoring: The Test Case Of Valoria Landslide

In the framework of the WISELAND project, funded by MIUR, we tested the integration between Lidar and hyperspectral methodologies in the Valoria landslide (Modena province, Italy), a high risk area with vulnerable elements, subjected to periodic and abrupt reactivations. Multitemporal Lidar Digital Terrain Models (DTMs) allowed the calculation of a differential surface, highlighting absolute height variations, recognizing the main landslide components and identifying depletion and accumulation zones. Hyperspectral data helped in the landslide terrain roughness characterization, performing the Principal Component Analysis (PCA) and correlating the results with Flatness and Organization geomorphometric parameters derived from Lidar DTM

The tectonic evolution of the Quadrilfitero Ferrifero, Minas Gerais, Brazil.

The structural framework of the Quadrilatero Ferrifero is the result of two main deformational events. The first is an extensional event of Palaeoproterozoic age (between 2100 and 1700 Ma, the Transamazonian Event), which resulted in the formation of Archaean granite-gneiss domes and the nucleation of regional synclines in the overlying Rio das Velbas and Minas supergroups strata. Such regional synclines are continuous with each other and are bordered by structural granite-gneiss highs. At the contact between these units, ductile-brittle to ductile extensional shear zones are developed, representing the dislocation surfaces of Archaean blocks. This tectonism is probably related to the evolution of a metamorphic core complex, formed in the hinterland to the west of a Transamazonian collision zone, which structured the Paramirim Craton. The second event is compressive and associated with the closure of the Pan-African/Brasiliano protoocean (650-500 Ma), situated to the east of Quadrilltero Ferrffero (QF). During this event, a west-verging foldandthrust belt (FTB) developed, causing inversion, amplification, translation and rotation of the basinal synclines. The FTB affected mainly the eastern portion of QF and obliterated many of the tectonic features of the extensional event

The usefulness of Moynihan questionnaire in the evaluation of knowledge on healthy diet of patients undergoing cardiology rehabilitation

BACKGROUND: The aim of study was to test the usefulness of Moynihan questionnaire in the evaluation of knowledge on healthy diet of patients undergoing cardiology rehabilitation. METHODS: We enrolled 51 patients (pts): 41 men and 10 women, mean age 67.97 +/-11.2 years. The case study included: 21 pts that underwent coronary bypass surgery, 16 pts replaced plastic tube, 14 pts had surgery for the other reasons. All pts underwent nutritional investigation by a dietitian. Anthropometric and biochemical parameters were detected and, by the end, the Moynihan questionnaire was administrated. Pts underwent nutritional coaching, and questionnaire and dietary assessment were rechecked after 3 months. RESULTS: At baseline, the mean Questionnaire score was 22.4 +/- 3.2 points, decreased to 20.6 +/-3.1 points after 3 months (p<0.05). A detailed analysis of the questions showed that the major informations gaps were related to consumption of fruits and vegetables, consumption of fat and salt. In addition pts have acquired more general knowledge about food composition. CONCLUSIONS: The Moynihan questionnaire is an useful instrument of evaluation of dietary knowledge even in selected patients population. In the present study involving patients after cardiac surgery the main difficulties were related to high age of pts, the low cultural level and, mainly, to the post-surgery stress. However, an increase of correct answers as well as an increased knowledge about food composition were detected after educational intervention performed by the dietitian

The MOCAST+ Study on a Quantum Gradiometry Satellite Mission with Atomic Clocks

In the past twenty years, satellite gravimetry missions have successfully provided data for the determination of the Earth static gravity field (GOCE) and its temporal variations (GRACE and GRACE-FO). In particular, the possibility to study the evolution in time of Earth masses allows us to monitor global parameters underlying climate changes, water resources, flooding, melting of ice masses and the corresponding global sea level rise, all of which are of paramount importance, providing basic data on, e.g. geodynamics, earthquakes, hydrology or ice sheets changes. Recently, a large interest has developed in novel technologies and quantum sensing, which promise higher sensitivity, drift-free measurements, and higher absolute accuracy for both terrestrial surveys and space missions, giving direct access to more precise long-term measurements. Looking at a time frame beyond the present decade, in the MOCAST+ study (MOnitoring mass variations by Cold Atom Sensors and Time measures) a satellite mission based on an “enhanced” quantum payload is proposed, with cold atom interferometers acting as gravity gradiometers, and atomic clocks for optical frequency measurements, providing observations of differences of the gravitational potential. The main outcomes are the definition of the accuracy level to be expected from this payload and the accuracy level needed to detect and monitor phenomena identified in the Scientific Challenges of the ESA Living Planet Program, in particular Cryosphere, Ocean and Solid Earth. In this paper, the proposed payload, mission profile and preliminary platform design are presented, with end-to-end simulation results and assessment of the impact on geophysical applications

The usefulness of Moynihan questionnaire in the evaluation of knowledge on healthy diet of patients undergoing cardiology rehabilitation

Background. The aim of study was to test the usefulness of Moynihan questionnaire in the evaluation of knowledge on healthy diet of patients undergoing cardiology rehabilitation. Methods. We enrolled 51 patients (pts): 41 men and 10 women, mean age 67.97 + 11.2 years. The case study included: 21 pts that underwent coronary bypass surgery, 16 pts replaced plastic tube, 14 pts had surgery for the other reasons. All pts underwent nutritional investigation by a dietitian. Anthropometric and biochemical parameters were detected and, by the end, the Moynihan questionnaire was administrated. Pts underwent nutritional coaching, and questionnaire and dietary assessment were rechecked after 3 months. Results. At baseline, the mean Questionnaire score was 22.4 + 3.2 points, decreased to 20.6 + 3.1 points after 3 months (p<0.05). A detailed analysis of the questions showed that the major informations gaps were related to consumption of fruits and vegetables, consumption of fat and salt. In addition pts have acquired more general knowledge about food composition. Conclusions. The Moynihan questionnaire is an useful instrument of evaluation of dietary knowledge even in selected patients population. In the present study involving patients after cardiac surgery the main difficulties were related to high age of pts, the low cultural level and, mainly, to the post-surgery stress. However, an increase of correct answers as well as an increased knowledge about food composition were detected after educational intervention performed by the dietitian